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Metabolic & Fat Loss Preclinical / Research Only PubChem CID: 162464

5-Amino-1MQ: Clinical Mechanism, Dossier & Protocols

Small molecule / peptide-adjacent oral compound that selectively inhibits Nicotinamide N-methyltransferase (NNMT), revitalizing cellular metabolism and accelerating adipocyte shrinkage.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
159.21 g/mol
Chemical Formula
C10H10N2
CAS Registry Number
42464-96-0
Elimination Half-Life
Approx. 6 - 8 hours
Administration Route
Oral (Capsules)
NCBI PubChem Record
Amino Acid Sequence: Small molecule: C10H11N2+

⚙️ Primary Mechanism of Action

Inhibits NNMT enzyme in adipose and muscle tissues, increasing intracellular NAD+ and SAM levels, which ramps up basal metabolic rate and inhibits fat cell expansion.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
Oral 50mg / 100mg capsules
Recommended Diluent
Target Research Dose
50mg - 150mg daily
Administration Frequency
Once or twice daily with meals
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Pregnancy / nursing
  • Severe hepatic disease

Documented Side Effects

  • Mild insomnia if taken late
  • Dry mouth
  • Slight jitteriness in sensitive individuals

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Biochemical Pharmacology (2018; 147:244-252)
Demonstrated selective NNMT inhibition upregulates NAD+ salvage and enhances myoblast differentiation in damaged muscular tissue.
PMID: 29248450

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