PHYSIOLOGICAL OBJECTIVE
Peptides for Longevity & Epigenetic Anti-Aging
Peptide bioregulators and senolytic compounds designed to restore pineal melatonin synthesis, lengthen telomeres, enhance mitochondrial respiration, and clear senescent cells.
Telomerase Reverse TranscriptaseFOXO4-p53Mitochondrial MOTS-cPineal Epithalamin
🏆 Ranked Peptides for Peptides for Longevity & Epigenetic Anti-Aging
| Peptide | Efficacy Tier | Clinical Rationale | Dosage Summary |
|---|---|---|---|
| Epithalon (Epitalon) | Gold Standard | Upregulates telomerase enzyme activity and normalizes circadian pineal melatonin production in 30+ year clinical trials. | 5mg - 10mg daily for 10-20 consecutive days, repeated 1-2 times per year. |
| MOTS-c | High Efficacy | Mitochondrial-derived peptide that activates AMPK, restores metabolic flexibility, and mimics exercise benefits. | 5mg - 10mg three times weekly for 4-6 weeks. |
| FOXO4-DRI | Emerging Research | Targeted senolytic peptide that disrupts the FOXO4-p53 axis to induce selective apoptosis in senescent cells. | 2mg - 5mg every other day for 3 doses. |
📋 Clinical Protocol Recommendation
Annual or bi-annual courses of Epithalon (10mg/day for 10 days) supported by mitochondrial enhancers like MOTS-c or SS-31.
Frequently Asked Questions
❓ How often should an Epithalon cycle be repeated?
Khavinson research protocols typically administer 10mg daily for 10 to 20 days, repeating the cycle once or twice annually.