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Longevity & Cellular Health Phase 2 / Phase 3 Clinical Trials PubChem CID: 21921319

Epithalon (Epitalon): Clinical Mechanism, Dossier & Protocols

Synthetic tetrapeptide based on pineal gland extract that activates telomerase, elongates telomeres, normalizes circadian rhythms, and extends healthy biological lifespan in mammalian studies.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
390.35 g/mol
Chemical Formula
C14H22N4O9
CAS Registry Number
307297-39-8
Elimination Half-Life
Short serum half-life (~1 hour); epigenetic and telomeric upregulation persists for months
Administration Route
Subcutaneous (SC), Intramuscular (IM), Nasal Spray
NCBI PubChem Record
Amino Acid Sequence: Ala-Glu-Asp-Gly

⚙️ Primary Mechanism of Action

Binds histone proteins to trigger epigenetic chromatin unraveling, reactivates the enzyme telomerase in somatic cells, restores melatonin secretion rhythms, and suppresses chromosomal aberrations.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
10mg, 50mg, 100mg
Target Research Dose
Classic Khavinson Protocol: 5mg - 10mg daily for 10 - 20 consecutive days, repeated 1 - 2 times per year.
Administration Frequency
Once daily morning or evening during protocol cycle
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • None documented in clinical literature; remarkably high safety ceiling.

Documented Side Effects

  • Vivid dreams during initial days
  • Mild injection site redness

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Bulletin of Experimental Biology and Medicine (2003; 135:590-592)
Reported activation of telomerase reverse transcriptase (TERT) and elongation of telomeres past the Hayflick cellular division limit.
PMID: 12937617 · DOI: 10.1023/a:1025493705728

⚖️ Head-to-Head Comparisons Featuring Epithalon (Epitalon)

Epithalon vs SS-31: Telomere Elongation vs Mitochondrial Cardiolipin Rejuvenation

Epithalon works at the nuclear genomic level by activating telomerase and normalizing circadian pineal function. SS-31 w...

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💧 Epithalon (Epitalon) Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator