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Metabolic & Fat Loss Phase 2 Clinical Trials PubChem CID: 138139589

MOTS-c: Clinical Mechanism, Dossier & Protocols

Mitochondrial-derived peptide encoded in the 12S rRNA that regulates metabolic homeostasis, activates AMPK, reverses insulin resistance, and acts as a profound exercise-mimetic.

Reconstitution Guide Syringe Calculator BAC Water Guide

🔬 Molecular Architecture & Physical Specifications

Molecular Weight
2174.6 g/mol
Chemical Formula
C101H152N28O22S2
CAS Registry Number
1627580-64-6
Elimination Half-Life
Approx. 4 hours in circulation; cellular epigenetic effects persist for days
Administration Route
Subcutaneous (SC), Intramuscular (IM)
NCBI PubChem Record
Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

⚙️ Primary Mechanism of Action

Translocates to the nucleus under metabolic stress to regulate nuclear gene expression; targets the folate-methionine cycle, elevates AICAR levels, and robustly activates 5′-AMP-activated protein kinase (AMPK).

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
5mg, 10mg
Target Research Dose
5mg to 10mg per injection, 2 - 3 times per week
Administration Frequency
2-3x weekly (e.g. Mon/Wed/Fri fasted morning or pre-workout)
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Acute hypoglycemia risk in brittle diabetics without monitoring

Documented Side Effects

  • Mild muscle soreness
  • Flushing
  • Fatigue if underfueled (due to rapid glucose clearance)

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Cell Metabolism (2015; 21:443-454)
Pioneering study showing MOTS-c regulates the folate-methionine cycle, activates AMPK, and increases skeletal muscle glucose disposal.
PMID: 25738459 · DOI: 10.1016/j.cmet.2015.02.009

Explore Related Research Modules

Access exact dilution guides, syringe unit calculators, and purity certificates for MOTS-c.

💧 MOTS-c Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator