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Healing & Tissue Repair Phase 2 Clinical Trials PubChem CID: 91826629

ARA-290 (Cibinetide): Clinical Mechanism, Dossier & Protocols

11-amino acid peptide derived from erythropoietin (EPO) that selectively activates the Innate Repair Receptor (IRR) without stimulating erythropoiesis, reversing small fiber neuropathy and neuropathic pain.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
1259.4 g/mol
Chemical Formula
C51H84N16O21
Elimination Half-Life
Approx. 20 - 30 minutes (tissue receptor signaling triggers long-term repair)
Administration Route
Subcutaneous (SC)
NCBI PubChem Record
Amino Acid Sequence: pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser

⚙️ Primary Mechanism of Action

Selectively binds the tissue-protective erythropoietin receptor / CD131 heterodimer (Innate Repair Receptor), halting inflammation and stimulating axonal and nerve fiber regeneration.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
10mg, 16mg, 20mg
Target Research Dose
4mg daily SubQ
Administration Frequency
Once daily for 28-30 consecutive days
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • None major identified; does not elevate red blood cell count unlike parent EPO.

Documented Side Effects

  • Mild injection site reaction
  • Occasional headache
  • Transient fatigue

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Molecular Medicine (2012; 18:1347-1354)
Activates the tissue-protective beta-common receptor without stimulating erythropoiesis or increasing hematocrit.
PMID: 22976761

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💧 ARA-290 (Cibinetide) Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator