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Growth Hormone Secretagogue Preclinical / Research Only PubChem CID: 91826956

CJC-1295 (No DAC) / Mod GRF 1-29: Clinical Mechanism, Dossier & Protocols

Tetrasubstituted 29-amino acid GHRH analog engineered for enhanced metabolic stability, inducing natural pulsatile Growth Hormone and IGF-1 secretion without desensitizing receptors.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
3367.9 g/mol
Chemical Formula
C152H252N44O42
CAS Registry Number
863288-34-0
Elimination Half-Life
Approx. 30 minutes (compared to 5-10 mins for native Sermorelin)
Administration Route
Subcutaneous (SC)
NCBI PubChem Record
Amino Acid Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

⚙️ Primary Mechanism of Action

Binds GHRH receptors on pituitary somatotropes, triggering natural physiological release pulses of endogenous Growth Hormone in synchronization with somatostatin valleys.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
2mg, 5mg
Target Research Dose
100mcg - 200mcg per injection (typically paired with 100mcg-200mcg Ipamorelin)
Administration Frequency
1 - 3 times daily (most critically before bed on an empty stomach)
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Active malignancy / pituitary adenoma
  • Pregnancy

Documented Side Effects

  • Transient facial flushing
  • Mild head rush for 10-15 mins post-injection
  • Water retention / tingling fingers if dosed excessively

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Journal of Clinical Endocrinology & Metabolism (2006; 91:799-805)
Clinical investigation demonstrating tetrasubstituted GHRH analogues preserve normal diurnal sleep-associated pulsatile growth hormone waves.
PMID: 16352683 · DOI: 10.1210/jc.2005-1536

⚖️ Head-to-Head Comparisons Featuring CJC-1295 (No DAC) / Mod GRF 1-29

CJC-1295 (No DAC) vs Sermorelin: Comparing GHRH Analogs for GH Secretion

CJC-1295 (No DAC / Mod GRF 1-29) is a tetrasubstituted modified version of Sermorelin with 4 amino acid substitutions th...

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