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Nootropic & Cognitive Preclinical / Research Only PubChem CID: 24847953

Dihexa: Clinical Mechanism, Dossier & Protocols

Oligopeptide-derived small molecule with extraordinary neurogenic potency, facilitating synaptogenesis and Hepatocyte Growth Factor (HGF) activation at seven orders of magnitude greater than BDNF.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
508.7 g/mol
Chemical Formula
C27H44N4O5
Elimination Half-Life
Approx. 12 days biological effect / high metabolic resilience
Administration Route
Oral, Sublingual, Topical / Transdermal (with DMSO)
NCBI PubChem Record
Amino Acid Sequence: N-Hexanoic-L-Tyr-L-Ile-aminohexanoic acid amide

⚙️ Primary Mechanism of Action

High-affinity binder to Hepatocyte Growth Factor (HGF), potentiating its dimerization and activating the c-Met receptor kinase, which drives massive new dendritic arborization and synaptic spine creation.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

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Standard Vial Sizes
Capsules 10mg / Powder 500mg
Target Research Dose
5mg to 15mg orally / sublingually 1 - 2 times per week (or 10mg-20mg transdermally)
Administration Frequency
1 - 2 times weekly (NOT daily, due to profound persistent synaptic plasticity)
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Strictly contraindicated with any history or suspicion of oncological disease (c-Met activation).

Documented Side Effects

  • Brain fog / overstimulation if over-dosed
  • Irritability
  • Theoretical concern for accelerating existing undiagnosed tumors (due to potent c-Met pathway activation)

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Journal of Pharmacology and Experimental Therapeutics (2013; 344:332-340)
Demonstrated sub-picomolar potency in activating hepatocyte growth factor (HGF) signaling, driving extensive dendritic spine arborization.
PMID: 23077143 · DOI: 10.1124/jpet.112.199497

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💧 Dihexa Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator