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Growth Hormone Secretagogue Preclinical / Research Only PubChem CID: 16131447

IGF-1 LR3: Clinical Mechanism, Dossier & Protocols

Recombinant 83-amino acid analog of human IGF-1 modified with an Arg substitution and 13-amino acid N-terminal extension that drastically lowers binding to inhibitory IGFBPs, resulting in extraordinary potency.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
9111.0 g/mol
Chemical Formula
C400H625N111O115S9
Elimination Half-Life
Approx. 20 - 30 hours (compared to 15 mins for native IGF-1)
Administration Route
Subcutaneous (SC), Intramuscular (IM)
NCBI PubChem Record
Amino Acid Sequence: 83-amino acid recombinant polypeptide with Arg3 substitution and N-terminal extension

⚙️ Primary Mechanism of Action

Binds with high affinity to the IGF-1 receptor and insulin receptor hybrids; bypasses IGF-binding proteins (IGFBPs) to activate the PI3K/Akt/mTOR pathway, stimulating protein synthesis, hyperplasia, and satellite cell activation.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
1mg
Target Research Dose
20mcg to 50mcg daily (post-workout or morning)
Administration Frequency
Once daily on workout days
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Active cancer or history of malignancy (potent mitogen/cell growth promoter)
  • Diabetes without careful glucose control

Documented Side Effects

  • Hypoglycemia (if not consuming carbs)
  • Lethargy post-administration
  • Pumps and joint tightness

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Endocrinology (1990; 127:2786-2792)
Foundational study detailing how reduced binding protein affinity prolongs bioactivity and elevates cellular proliferative signaling.
PMID: 1695632

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💧 IGF-1 LR3 Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator