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Growth Hormone Secretagogue Phase 2 Clinical Trials PubChem CID: 9831659

Ipamorelin: Clinical Mechanism, Dossier & Protocols

Third-generation selective ghrelin receptor (GHSR-1a) agonist pentapeptide that stimulates pure Growth Hormone release without raising prolactin, cortisol, aldosterone, or appetite.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
711.85 g/mol
Chemical Formula
C38H49N9O5
CAS Registry Number
170851-70-4
Elimination Half-Life
Approx. 2 hours
Administration Route
Subcutaneous (SC)
NCBI PubChem Record
Amino Acid Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2

⚙️ Primary Mechanism of Action

Selectively binds pituitary GHSR-1a receptors, triggering a robust, clean release of endogenous Growth Hormone without the off-target prolactin, ACTH, or hunger surges seen with older GHRPs.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
2mg, 5mg, 10mg
Target Research Dose
100mcg - 300mcg per injection (paired 1:1 with CJC-1295 No DAC)
Administration Frequency
1 - 2 times daily (bedtime & morning fasted)
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Active cancers or pituitary lesions

Documented Side Effects

  • Mild lightheadedness shortly after injection
  • Slight site redness

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
European Journal of Endocrinology (1998; 139:552-561)
Foundational pharmacological discovery demonstrating Ipamorelin releases GH with unmatched selectivity, without raising ACTH, cortisol, or prolactin.
PMID: 9849822 · DOI: 10.1530/eje.0.1390552

Explore Related Research Modules

Access exact dilution guides, syringe unit calculators, and purity certificates for Ipamorelin.

💧 Ipamorelin Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator