⚡ Syringe Tool
Sexual & Hormonal Health Phase 2 Clinical Trials PubChem CID: 10442581

Kisspeptin-10: Clinical Mechanism, Dossier & Protocols

Endogenous decapeptide that governs the hypothalamic-pituitary-gonadal (HPG) axis, triggering natural GnRH, LH, and FSH release to restore endogenous testosterone and fertility.

Reconstitution Guide Syringe Calculator BAC Water Guide

🔬 Molecular Architecture & Physical Specifications

Molecular Weight
1302.4 g/mol
Chemical Formula
C63H83N17O14
Elimination Half-Life
Approx. 25 - 30 minutes (biological endocrine pulse triggers lasting cascade)
Administration Route
Subcutaneous (SC)
NCBI PubChem Record
Amino Acid Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

⚙️ Primary Mechanism of Action

Binds G-protein coupled receptor GPR54 (KISS1R) on hypothalamic GnRH neurons, stimulating pulsatile Gonadotropin-Releasing Hormone release, which prompts pituitary LH and FSH surges.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
5mg, 10mg
Target Research Dose
100mcg - 300mcg SubQ
Administration Frequency
2 - 3 times per week or acutely prior to intimate activity
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Hormone-sensitive prostate or reproductive cancers

Documented Side Effects

  • Mild flushing
  • Transient hot flashes
  • Headache if dosed too high

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Journal of Clinical Endocrinology & Metabolism (2009; 94:3989-3994)
Demonstrated intravenous and subcutaneous Kisspeptin-10 pulses stimulate robust endogenous LH and testosterone release.
PMID: 19723753 · DOI: 10.1210/jc.2009-0824

Explore Related Research Modules

Access exact dilution guides, syringe unit calculators, and purity certificates for Kisspeptin-10.

💧 Kisspeptin-10 Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator