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Healing & Tissue Repair Preclinical / Research Only PubChem CID: 122178

KPV: Clinical Mechanism, Dossier & Protocols

Naturally occurring C-terminal tripeptide fragment of alpha-Melanocyte-Stimulating Hormone (alpha-MSH) with potent anti-inflammatory, antimicrobial, and gut barrier restorative actions without pigment changes.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
383.49 g/mol
Chemical Formula
C16H30N4O4
Elimination Half-Life
Approx. 2 hours
Administration Route
Subcutaneous (SC), Oral (Enteric Capsule), Topical (Cream/Spray)
NCBI PubChem Record
Amino Acid Sequence: Lys-Pro-Val

⚙️ Primary Mechanism of Action

Enters the cell nucleus to directly inhibit NF-kappaB translocation and downregulate proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and exhibits antimicrobial activity against Candida albicans and S. aureus.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
5mg, 10mg
Target Research Dose
200mcg - 500mcg daily SubQ (or 250mcg - 500mcg orally for gut targeting)
Administration Frequency
Once to twice daily
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • None known

Documented Side Effects

  • Minimal to none observed; very high tolerability profile

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Peptides (2006; 27:415-423)
Demonstrates potent inhibition of NF-kappaB nuclear translocation, reducing intestinal mucosal mucosal inflammation.
PMID: 16289450

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