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Immune & Anti-Inflammatory Phase 2 Clinical Trials PubChem CID: 388834920

LL-37 (Cathelicidin): Clinical Mechanism, Dossier & Protocols

Human antimicrobial peptide with broad-spectrum bactericidal, antiviral, and antifungal efficacy, capable of disrupting stubborn pathogenic bacterial biofilms.

Reconstitution Guide Syringe Calculator BAC Water Guide

🔬 Molecular Architecture & Physical Specifications

Molecular Weight
4493.3 g/mol
Chemical Formula
C205H340N60O53
Elimination Half-Life
Approx. 1 - 2 hours (membrane disruption is immediate on contact)
Administration Route
Subcutaneous (SC), Topical / Nebulized (Research)
NCBI PubChem Record
Amino Acid Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

⚙️ Primary Mechanism of Action

Forms amphipathic alpha-helices that electrostatically bind negative bacterial cell walls, punching toroidal pores that lyse bacteria and break down tough polysaccharide biofilm matrices.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
5mg
Target Research Dose
100mcg - 250mcg daily SubQ
Administration Frequency
Once daily for brief targeted pulses
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Active autoimmune flare-ups with severe psoriasis (LL-37 can trigger psoriasis flares in susceptible genetics)

Documented Side Effects

  • Jarisch-Herxheimer die-off reactions (fatigue, chills, headache)
  • Injection site stinging

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Frontiers in Immunology (2018; 9:543)
Examines LL-37 bacterial membrane permeabilization mechanisms against gram-positive and gram-negative pathogens, alongside angiogenic stimulation.
PMID: 29556233 · DOI: 10.3389/fimmu.2018.00543

Explore Related Research Modules

Access exact dilution guides, syringe unit calculators, and purity certificates for LL-37 (Cathelicidin).

💧 LL-37 (Cathelicidin) Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator