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Cosmetic & Skin Preclinical / Research Only PubChem CID: 92432

Melanotan II: Clinical Mechanism, Dossier & Protocols

Synthetic cyclic heptapeptide analog of alpha-MSH that stimulates melanin production (eumelanin) for deep sunless skin tanning while simultaneously activating central sexual libido pathways.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
1024.18 g/mol
Chemical Formula
C50H69N15O9
Elimination Half-Life
Approx. 1 - 2 hours (biological skin melanin upregulation lasts weeks)
Administration Route
Subcutaneous (SC), Nasal Spray
NCBI PubChem Record
Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

⚙️ Primary Mechanism of Action

Non-selective melanocortin receptor agonist (MC1R for skin eumelanin production, MC3R/MC4R for appetite suppression and potent central sexual arousal stimulation in the hypothalamus).

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
10mg
Target Research Dose
Loading: 250mcg - 500mcg SubQ daily with brief UV exposure until desired tan is reached. Maintenance: 500mcg once weekly.
Administration Frequency
Daily during loading; weekly during maintenance
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Dysplastic nevus syndrome or history of melanoma
  • Severe hypertension

Documented Side Effects

  • Facial flushing for 30-60 mins after dose
  • Transient mild nausea
  • Darkening of existing freckles/moles
  • Spontaneous erections (priapism risk if overdosed)

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
European Journal of Pharmacology (2003; 462:1-8)
Clinical investigation of MC1R-mediated eumelanin pigment stimulation and central MC4R neuro-sexual pathways.
PMID: 12850573

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