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Sexual & Hormonal Health FDA Approved (Specific Indications) PubChem CID: 9941379

PT-141 (Bremelanotide): Clinical Mechanism, Dossier & Protocols

FDA-approved synthetic cyclic heptapeptide that acts centrally on the central nervous system to treat hypoactive sexual desire disorder (HSDD) and erectile dysfunction without vascular strain.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
1025.2 g/mol
Chemical Formula
C50H68N14O10
Elimination Half-Life
Approx. 2.7 hours (sexual responsiveness lasts 8 - 14 hours)
Administration Route
Subcutaneous (SC), Intranasal
NCBI PubChem Record
Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

⚙️ Primary Mechanism of Action

Acts as a central melanocortin MC4R and MC3R agonist in the medial preoptic area of the hypothalamus, modulating central dopaminergic neural circuits that govern sexual desire and arousal.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
10mg
Target Research Dose
1.0mg to 1.75mg SubQ administered 45 minutes to 2 hours prior to sexual activity
Administration Frequency
As needed (do not exceed 1 dose in 24 hours or 8 doses per month)
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Uncontrolled high blood pressure / cardiovascular disease
  • Concomitant naltrexone use

Documented Side Effects

  • Transient mild nausea (peaks 30m post-dose)
  • Facial flushing
  • Headache
  • Temporary slight increase in blood pressure

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Journal of Sexual Medicine (2019; 16:1548-1558)
Comprehensive clinical review establishing central nervous system MC4R agonist efficacy in modulating sexual desire and arousal.
PMID: 31473187

Explore Related Research Modules

Access exact dilution guides, syringe unit calculators, and purity certificates for PT-141 (Bremelanotide).

💧 PT-141 (Bremelanotide) Dilution Guide ⚡ Syringe Reconstitution Tool Bacteriostatic Water Monograph Tested Vendor Directory Cycle Cost Calculator