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Nootropic & Cognitive FDA Approved (Specific Indications) PubChem CID: 11765600

Selank: Clinical Mechanism, Dossier & Protocols

Synthetic heptapeptide analog of the human immunomodulatory peptide Tuftsin, engineered as a powerful non-sedating anxiolytic, mood enhancer, and immune-cognitive booster.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
751.9 g/mol
Chemical Formula
C33H57N11O9
CAS Registry Number
129954-34-3
Elimination Half-Life
Approx. 20 - 30 minutes; anxiolytic GABA-ergic modulation persists throughout the day
Administration Route
Intranasal (Nasal Spray), Subcutaneous (SC)
NCBI PubChem Record
Amino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro

⚙️ Primary Mechanism of Action

Modulates allosteric GABA-A receptors, stabilizes enkephalins by inhibiting enkephalinase enzymes, upregulates BDNF, and balances IL-6 and serotonin metabolism without sedation or addiction.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
10mg, 30mg
Target Research Dose
250mcg - 750mcg daily (Nasal spray: 1-2 sprays per nostril; or SubQ: 250-500mcg)
Administration Frequency
1 - 2 times daily as needed
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • None significant known

Documented Side Effects

  • Occasional nasal dryness with sprays
  • Mild fatigue if dosed very high

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Bulletin of Experimental Biology and Medicine (2008; 145:43-45)
Showed modulation of GABA-A receptor affinity without the sedating, addictive, or motor-impairing side effects of benzodiazepines.
PMID: 19089025

⚖️ Head-to-Head Comparisons Featuring Selank

Semax vs Selank: Nootropic Focus & BDNF vs Anxiolytic Calm & Mood

Semax is an energizing, BDNF-boosting nootropic that sharpens focus, executive function, and memory retention. Selank is...

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