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Nootropic & Cognitive FDA Approved (Specific Indications) PubChem CID: 3034285

Semax: Clinical Mechanism, Dossier & Protocols

Synthetic Russian-developed heptapeptide analog of adrenocorticotropic hormone (ACTH 4-10) with potent BDNF upregulation, cognitive enhancement, ADHD symptom relief, and neuroprotective properties.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
813.9 g/mol
Chemical Formula
C37H51N9O10S
CAS Registry Number
80714-61-0
Elimination Half-Life
Approx. 20 - 30 minutes in blood; neurochemical elevation of BDNF/TrkB persists for 24+ hours
Administration Route
Intranasal (Nasal Spray), Subcutaneous (SC)
NCBI PubChem Record
Amino Acid Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

⚙️ Primary Mechanism of Action

Boosts Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) mRNA expression in the hippocampus; modulates dopaminergic and serotonergic neurotransmission without hormonal ACTH side effects.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
10mg, 30mg, 60mg
Target Research Dose
200mcg - 600mcg daily (Nasal spray: 1-2 sprays per nostril; or SubQ: 250-500mcg)
Administration Frequency
1 - 2 times daily (morning & early afternoon)
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Acute psychosis or severe bipolar manic episodes

Documented Side Effects

  • Mild temporary headache from intense mental focus
  • Transient hair shedding with prolonged massive overuse (rare)
  • Insomnia if taken late

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Bulletin of Experimental Biology and Medicine (2006; 141:590-593)
Demonstrated rapid upregulation of Brain-Derived Neurotrophic Factor (BDNF) mRNA and trkB receptor signaling in cerebral tissue.
PMID: 17342240 · DOI: 10.1007/s10517-006-0230-z

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