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Growth Hormone Secretagogue FDA Approved (Specific Indications) PubChem CID: 16132446

Sermorelin: Clinical Mechanism, Dossier & Protocols

Bioidentical 29-amino acid functional fragment of human Growth Hormone-Releasing Hormone, restoring natural pituitary pulsatility and vitality with an outstanding clinical safety history.

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🔬 Molecular Architecture & Physical Specifications

Molecular Weight
3357.9 g/mol
Chemical Formula
C149H246N44O42S
Elimination Half-Life
Approx. 10 - 15 minutes
Administration Route
Subcutaneous (SC)
NCBI PubChem Record
Amino Acid Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

⚙️ Primary Mechanism of Action

Directly stimulates the pituitary gland to produce and secrete growth hormone naturally, operating within the body's negative feedback loop to eliminate risk of GH overdose.

💉 Research Dosage & Reconstitution Standard

Requires pharmaceutical-grade 0.9% benzyl alcohol Bacteriostatic Water to inhibit bacterial replication for multi-dose access.

Full Step-by-Step Guide →
Standard Vial Sizes
2mg, 5mg, 10mg
Target Research Dose
200mcg - 500mcg daily at bedtime
Administration Frequency
Once daily before sleep
💧 Dilution Standard: Reconstitute with sterile Bacteriostatic Water for Injection (USP). Aim stream gently along the vial glass wall to avoid foaming. Store reconstituted solution at 2°C to 8°C (36°F to 46°F) protected from light. Discard multi-dose punctured vials at 28 days pursuant to USP <797> standards. Never freeze reconstituted liquid.

⚠️ Contraindications & Documented Adverse Effects

Strict Contraindications

  • Active neoplasms / cancer
  • Known pituitary insufficiency

Documented Side Effects

  • Transient flushing / tingling
  • Mild redness at injection site
  • Headache during initial week

📚 Peer-Reviewed References & Authoritative Sources

Citations indexed in PubMed, National Center for Biotechnology Information (NCBI), and ClinicalTrials.gov.

1 VERIFIED CITATIONS
Clinical Interventions in Aging (2006; 1:307-319)
Evaluates the safety profile of GHRH 1-29 in stimulating physiological pituitary somatotroph release with negative feedback intact.
PMID: 18047120

⚖️ Head-to-Head Comparisons Featuring Sermorelin

CJC-1295 (No DAC) vs Sermorelin: Comparing GHRH Analogs for GH Secretion

CJC-1295 (No DAC / Mod GRF 1-29) is a tetrasubstituted modified version of Sermorelin with 4 amino acid substitutions th...

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Access exact dilution guides, syringe unit calculators, and purity certificates for Sermorelin.

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